Retatrutide

GLP-1, GIP, glucagon receptor triple agonist

Stocked in 10mg, 12mg, 15mg, 20mg, 30mg, 40mg, 50mg, 60mg at MontanaPep in Great Falls, Montana. Sold for laboratory research use only.

Sizes and pricing for Retatrutide
Size	Catalog no.	Price per vial
10mg	RT10	$35
12mg	RT12	$40
15mg	RT15	$45
20mg	RT20	$55
30mg	RT30	$70
40mg	RT40	$85
50mg	RT50	$100
60mg	RT60	$115

Classification

Synthetic triple GIP/GLP-1/glucagon receptor agonist

Structure and chemistry

Retatrutide (LY3437943) is a single peptide engineered to activate the GIP, GLP-1, and glucagon receptors. It is designed as a unimolecular triple agonist rather than a physical mixture of three separate peptides. The exact chemical form should be matched to the analytical reference standard.

What the published research shows

Retatrutide has progressed from preclinical triagonist research through first-in-human and Phase 1b studies, a major Phase 2 obesity program, and multiple Phase 3 programs. Current research includes obesity, type 2 diabetes, knee osteoarthritis, obstructive sleep apnea, cardiovascular and kidney outcomes, and metabolic-associated steatotic liver disease.

Mechanism of action

A single molecule with agonist activity at GIP, GLP-1 and glucagon receptors. The scientific rationale is to combine incretin effects with glucagon-receptor activity in one balanced molecular framework.

Development history

The scientific foundation for unimolecular GIP/GLP-1/glucagon triagonists predates retatrutide. Lilly subsequently developed LY3437943 and published discovery, receptor characterization and clinical proof-of-concept work before moving into Phase 2 and the large TRIUMPH/TRANSCEND Phase 3 programs.

Current regulatory status

Retatrutide remains investigational and is not FDA-approved. As of September 2026, Lilly describes its clinical development as Phase 3.

Analytical testing

HPLC/RP-HPLC and LC-MS provide complementary information for chromatographic purity and molecular identity. A COA should identify the exact molecular target and distinguish purity from content and identity.

Research use only. MontanaPep supplies Retatrutide exclusively for in-vitro laboratory research. It is not sold as a drug, food, cosmetic or supplement and is not for human or veterinary use. This page is a reference summary of published literature and regulatory records. Material is produced by pharmaceutical API manufacturers; how that process works is described in our research library.

Ordering from Great Falls

MontanaPep, also known as Montana Peptides, is an independently owned supplier based at 715 13th Ave S, Great Falls, Montana. Local pickup is available by arrangement, and we ship to research addresses across Montana including Billings, Missoula, Bozeman, Helena, Butte, Kalispell and Havre. Call (406) 799-0812 or email customerservice@montanapep.com.