KissPeptin-10
Stocked in 5mg vials, 10mg vials at MontanaPep in Great Falls, Montana. Sold for laboratory research use only.
| Size | Catalog no. | Price per vial |
|---|---|---|
| 5mg vials | KS5 | $25 |
| 10mg vials | KS10 | $40 |
Classification
Endogenous neuropeptide fragment sitting at the apex of the reproductive axis
Structure and chemistry
Kisspeptin-10 is the C-terminal 10 amino acids of the kisspeptin peptide family, also written metastin(45-54) or Kp-10. The KISS1 gene on chromosome 1q32 encodes a 145-residue precursor, which is cleaved to a 54-residue peptide (kisspeptin-54, originally named metastin), and further to 14-, 13- and 10-residue fragments. All belong to the RF-amide family, sharing a C-terminal Arg-Phe-NH2 — and that terminal amidation is essential to biological activity, not incidental. Kisspeptin-10 is the shortest fragment retaining full receptor activity.
What the published research shows
Kisspeptin has a strong, genuinely foundational research literature: human genetics, knockout mice, receptor pharmacology, and controlled human administration studies. Two findings from that literature deserve particular attention because they cut against intuitive use. First, continuous exposure desensitizes the receptor and lowers rather than raises gonadotropins. Second, high-dose kisspeptin-54 acutely induced testicular degeneration in adult male rats through central mechanisms.
Mechanism of action
Kisspeptin acts upstream of gonadotropin-releasing hormone neurons in the hypothalamus, through the receptor KISS1R (originally the orphan receptor GPR54, also called AXOR12 and hOT7T175). It is described as sitting at the apex of the reproductive axis: kisspeptin drives GnRH release, which drives LH and FSH, which drive the gonads. Its original identification was unrelated to reproduction — it was found as a metastasis-suppressing gene product, and it inhibits chemotaxis and invasion of cancer cells in experimental systems.
Development history
Kisspeptin was not developed as a drug. In 1996 Danny Welch and colleagues, working in Hershey, Pennsylvania, identified KISS1 as a metastasis-suppressor gene in malignant melanoma. They named it after the town’s most famous product, Hershey’s Kisses. Its reproductive role emerged seven years later and entirely by a separate route.
Current regulatory status
Kisspeptin-10 is not approved by the FDA or any regulator for any indication. FDA placed kisspeptin-10 in Category 2 of the 503A interim bulk drug substances list on 29 September 2023.
Analytical testing
Two identity features matter beyond a purity number. The C-terminal Arg-Phe amide is required for activity, and a free-acid version differs by only about 1 dalton — the mass-spectrometry method must be able to resolve that. Kisspeptin-10 also contains an oxidation-prone residue and is known to be susceptible to degradation, so storage handling and a genuine stability assessment matter more here than for a robust short peptide.
Ordering from Great Falls
MontanaPep, also known as Montana Peptides, is an independently owned supplier based at 715 13th Ave S, Great Falls, Montana. Local pickup is available by arrangement, and we ship to research addresses across Montana including Billings, Missoula, Bozeman, Helena, Butte, Kalispell and Havre. Call (406) 799-0812 or email customerservice@montanapep.com.