PE-22-28
Stocked in 10mg at MontanaPep in Great Falls, Montana. Sold for laboratory research use only.
| Size | Catalog no. | Price per vial |
|---|---|---|
| 10mg | PE10 | $40 |
Classification
Synthetic seven-residue fragment of spadin; a TREK-1 channel blocker
Structure and chemistry
PE-22-28 corresponds to residues 22 to 28 of spadin, itself derived from the propeptide released during maturation of sortilin. The shortened sequence was designed to retain affinity for the target while improving stability over the parent 12-residue molecule.
What the published research shows
The work centres on the TREK-1 two-pore-domain potassium channel as an antidepressant target, following the finding that TREK-1 knockout mice display an antidepressant-like phenotype. Rodent studies from Marc Borsotto, Catherine Heurteaux and colleagues at the Institut de Pharmacologie Moléculaire et Cellulaire in France report rapid-onset antidepressant-like behaviour and increases in hippocampal neurogenesis. There is no published human clinical data of any kind.
Mechanism of action
Blocks the TREK-1 channel. This is mechanistically distinct from monoamine reuptake inhibition, and the interest in it stems from the speed of onset reported in animals compared with conventional antidepressants.
Development history
An academic research compound. It has not entered clinical trials and has no registry presence.
Current regulatory status
Not approved by the FDA. Entirely preclinical. Supplied for laboratory research use only.
Analytical testing
Identity by mass spectrometry, purity by HPLC. A short sequence, so mass confirmation is straightforward and should be expected on the COA.
Ordering from Great Falls
MontanaPep, also known as Montana Peptides, is an independently owned supplier based at 715 13th Ave S, Great Falls, Montana. Local pickup is available by arrangement, and we ship to research addresses across Montana including Billings, Missoula, Bozeman, Helena, Butte, Kalispell and Havre. Call (406) 799-0812 or email customerservice@montanapep.com.